The early phase CRO for clinical trials in neurology and psychiatry
We design and conduct proof of concept studies to accelerate the development of your drug or medical device in brain diseases.
About Neurotrials
Neurotrials is a Contract Research Organization (CRO) offering clinical research services to the Healthcare product industry.
Neurotrials is specialized in the design and conduct of early phase clinical trials in neurology and psychiatry. Made of highly skilled professionals from academic and industrial backgrounds, Neurotrials leverages its unique ecosystem comprising experts, patients and cutting-edge research technologies to accelerate your product development with innovative solutions, dependability and cost-efficiency.
Services
Neurotrials simplifies your life and operates as a full-service CRO, offering comprehensive study services with a single partner.
Neurotrials also provides "à-la-carte" solutions, tailoring our services to your specific needs.
Scientific and Medical Consulting
Neurotrials helps you design your clinical trial in collaboration with Key Opinion Leaders who are world-renowned specialists.
- Identification of product strengths and weaknesses; refinement of indication and scientific rational
- Appraisal of patient populations, medical practices and medical needs; product positioning
- Protocol development: proposition of study design, study population, objectives and endpoints, sample size
- Clinical study cost estimate
Regulatory affairs
Our regulatory affairs experts guide you through the regulatory process.
- Regulatory strategy and consulting
- Clinical Trial Application & Maintenance (regulatory agencies and ethics committees)
- Responses to regulatory questions
- Scientific advices, communication with regulatory agencies
- Orphan Drug Designation Applications
- Regulatory intelligence
Study Conduct
Neurotrials helps you design, start-up and manage your clinical trials to successful Completion.
- Clinical operation: Site selection, initiation, monitoring, close-out
- Data management
- Biostatistics
- Pharmacovigilance
- Quality assurance
Medical Writing
Neurotrials provides medical writing support according to your needs.
- Synopsis, Protocols and Amendments
- Informed Consent Forms
- Clinical Study Reports
- Investigator’s Brochures and IMPDs
- IND overviews and summaries
- Briefing Books for scientific advices
- Technical files / Clinical Evaluation Reports (Medical device)
- Annual safety reports
Scopes
- First-in-patient / proof-of-concept studies
- Small-scale studies
- Access to targeted patient cohorts (common or rare profiles)
- Biomarker identification and assessment
- Genotyping and phenotyping approaches to characterize specific patient populations
- Advanced research tools, techniques and access to ultra-specialized platforms
Neurotrials supports your Medical device pre and post marketing activities
- Medical devices with a Neurological and/or psychiatric indication
- All classes of Medical devices (from Class I ou Class III) with various technologies
Resources
Clinical Investigation Centre
The Neurosciences Clinical Investigation Centre (CIC) is a platform of excellence dedicated to clinical research conducting over 100 interventional or observational clinical trials and handling more than 2000 patients’ visits each year. Headed by Pr. Jean-Christophe Corvol, the GCP-trained staff of the CIC manages studies in numerous neurological and psychiatric disorders.
100
clinical trials/year
2000
patient visits/year
Area of expertise
Other platforms
Several other platforms specifically dedicated to research are available for your trials
CENIR-PANAM
Clinical and therapeutic research using non-invasive brain stimulation in neurological and psychiatric diseases, the study of movement, gait and balance in patients with neurological diseases.
CENIR-huMRI
The Centre for Neuroimaging Research - CENIR is the imaging platform of the Paris Brain Institute.<br>
This platform consists of:<br>
- 3 dedicated 3T MRI<br>
- TMS / tdCS / high Density EEG
TEP-MRI
Combination of nuclear imaging with Magnetic Resonance Imaging (MRI). This GE SIGNA integrated PET/MR system allows simultaneous PET and 3T MR imaging without moving the subject in addition to being able to measure the time of flight of the PET emission data
CENIR-STIM
Offers support for analysis and software development based on stereotactic imaging data (used for deep brain stimulation, drug-resistant epilepsy and radiosurgery, among others)
CENIR-PRISME
Platform dedicated to the functional exploration of human behavior, PRISM is divided into 2 entities: PRISM-Virtual Reality and PRISM-Real Life
CENIR-MEG EEG
Dedicated to the development of non-invasive methods that allow the visualization of brain activity with a temporal resolution of the order of a millisecond under normal or pathological conditions.
DNA & Cells Bank
The Paris Brain Institute's DNA and Cell Bank manages a set of collections of biological resources for medical research projects, most of which relate to neurological and psychiatric diseases. These samples include, for example:
- 55 000+ Brain samples
- 5000+ Multiple Sclerosis samples
- 7000+ Glioma RMI samples
Genotyping & Sequencing
The platform provides tools and services for genome analysis to academics or industrials. More specifically, services include real-time PCR, digital PCR, sequencing, as well as purification and analysis of nucleic acids. This platform masters the techniques of high throughput sequencing and can also provide medium-throughput new generation sequencing.
Download our one pager
Our network
Neurotrials is hosted within the Paris Brain Institute, a European leader in neuroscience, itself located at the heart of the university hospital la Pitié Salpêtrière.
The Pitié-Salpêtrière Hospital is part of the University Medical Neurosciences Department affiliated with the Sorbonne University, which integrates 5 hospitals with neurological and psychiatric activities: Pitié-Salpêtrière, Tenon, Rothschild, Saint-Antoine and Charles Foix Hospitals.
Through this unique network of expertise, Neurotrials offers excellence in scientific consulting and clinical trials to its customers.
Team
Dr Louise-Laure MARIANI
Head of Neurotrials & Medical Lead
MD, PhD
Louise-Laure Mariani (MD, PhD) is a Neurologist and Neuroscientist, with a specialization in neuropharmacology. She has an expertise in neurological disorders, such as Parkinson’s disease, cerebellar ataxia, other movement disorders and neurogenetics. Dr MARIANI works as an Associate Professor of neuropharmacology at the Pitié-Salpêtrière Hospital (Paris, Sorbonne University), and as an investigator at the Clinical Investigation Center located in the Paris Brain Institute. She works in close collaboration with the various french reference centers for neurological diseases.
Pierre GEORGES FRANCOIS
Clinical Operation Manager
MSc
Pierre Georges François has been working in the field of clinical development for more than 15 years within the Pharma industry and CROs, 10 years of which having been spent within Ipsen, where he managed clinical trials in various therapeutic areas, from Phase I first-in-Man clinical trials to pivotal phase III trials.
Maud JOURDAN
Clinical Project Manager
MSc
After working several years in fondamental stem cell research as an Engineer at the French Institute of Health and Medical Research (INSERM), she specialized in clinical research. Maud worked as a consultant for the leading academic promoter of oncology clinical trials in Europe.
She joined Neurotrials as a Clinical Research Associate to work on early phase clinical trial in brain disease.
Jennifer THIBAULT
Clinical Project Manager
MSc
Jennifer Thibault holds a Master in Ethology from Paris XIII University and a Master’s Degree in Cognitive and Behavioural Neuroscience, from Sorbonne University.
After working as a research assistant in fundamental research in Neuroscience (Montreal, Canada), she worked in Paris in international CROs as a monitor Clinical Research Associate. She then specialized in start-up unit, first as a specialized Clinical Research Associate in sites’ selection and then as a start-up Regulatory Specialist, with the Project team leader cap.
Julien SERUSCLAT
Medical writer
PharmD-MSc
Julien Serusclat is an industrial pharmacist. He graduated from Paris-Saclay University with a specialization in regulatory affairs. He has been supporting the clinical development of a wide range of investigational drugs, from the small chemical compound to the neural stem cell, within small and big pharma abroad (Switzerland and UK) before returning to France to join the Paris Brain Institute. Julien has an extensive experience in writing scientific, clinical and regulatory documents.
Jennifer IDUSOGIE
Regulatory Affairs Officer
PharmD-MSc
Jennifer Idusogie is a pharmacist graduated from the University of Clermont-Auvergne and completed her curriculum with a Master's degree in Regulatory Affairs. She has supported regulatory affairs activities in the pharmaceutical industry on drug development and post-marketing projects.